Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 551 (7680)

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Sci. Signal.  21 Nov 2017:
Vol. 10, Issue 506, eaar5179
DOI: 10.1126/scisignal.aar5179

This week’s articles identify a mechanism by which liver inflammation suppresses antitumor immunity; a bacterial effector protein that targets host defense proteins for degradation; and a signaling mechanism for detecting and repairing a specific type of DNA damage.

CANCER IMMUNOLOGY

Inflammation inhibits antitumor immunity

Shalapour et al. demonstrate that a subset of B cells contributes to the development of hepatocellular carcinoma in mice and humans with nonalcoholic fatty liver disease by suppressing the activation of antitumor T cells.

HOST-PATHOGEN INTERACTIONS

Targeting GBPs to disrupt host defense

Li et al. report that a Shigella flexneri effector protein targets host antimicrobial guanylate-binding proteins for degradation (see also commentary by MacMicking).

DNA REPAIR

Undoing alkylation damage

Brickner et al. describe a ubiquitin-dependent signaling mechanism for detecting and repairing DNA alkylation.

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