Contents
28 November 2017
Vol 10, Issue 507
Vol 10, Issue 507
Focus
- Opening the Orai1 gates
Two gates and a transmembrane site are required to open the store-operated channel Orai1.
Research Articles
- Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription
Characterization of disease-associated Orai1 mutants reveals the multistep gating mechanism for the CRAC channel.
- MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)–addicted neuroblastomas
MEK inhibitors induce feedback AKT-mTORC2–mediated survival signaling in ALK-addicted neuroblastoma cells.
- Arabidopsis ATXR2 deposits H3K36me3 at the promoters of LBD genes to facilitate cellular dedifferentiation
The histone lysine methyltransferase ATXR2 promotes cellular dedifferentiation in Arabidopsis thaliana.
- Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis
Activation of an enzymatically oxidized phospholipid network from blood cells contributes to a human thrombotic disorder.
Editors' Choice
- CAFs complicate immunotherapy
Anti-CSF1R immunotherapy effectively inhibits one suppressive immune cell type but unleashes another through cancer-associated fibroblasts.
- Papers of note in Science 358 (6366)
This week’s articles highlight structural insights into peptide loading of MHC; the mechanism by which light opens a channel protein; and how regulation of a host metabolic enzyme affects viral replication.
- Papers of note in Science Translational Medicine 9 (417)
This week’s articles describe a better diagnostic marker for pediatric biliary atresia and insights into CAR T cell biology that may enable optimization of CAR T cell–based therapy.
- Papers of note in Science Immunology 2 (17)
This month’s articles show how a hypha-associated fungal peptide triggers an antifungal immune response and how the lipid PIP2 sustains B cell receptor signaling.
About The Cover
Online Cover This week features a Research Article that reveals the multistep gating mechanism for the calcium-release activated calcium (CRAC) channel Orai1 through the characterization of disease-associated mutants (see also the accompanying Focus). The image shows a representative snapshot of the equilibrated part of a molecular dynamics simulation for wild-type Orai1. [Image: Frischauf et al./Science Signaling]