FocusIon Channels

Opening the Orai1 gates

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Sci. Signal.  28 Nov 2017:
Vol. 10, Issue 507, eaaq0618
DOI: 10.1126/scisignal.aaq0618

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Abstract

How the store-operated channel Orai1 opens and the number of gates that control channel opening and conductance remain unclear. In this issue of Science Signaling, Frischauf et al. report on the importance of the basic pore region in addition to the hydrophobic gate in channel gating and identify a site in transmembrane domain 2 (TM2) that controls pore opening.

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