Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 358 (6366)

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Sci. Signal.  28 Nov 2017:
Vol. 10, Issue 507, eaar5580
DOI: 10.1126/scisignal.aar5580

This week’s articles highlight structural insights into peptide loading of MHC; the mechanism by which light opens a channel protein; and how regulation of a host metabolic enzyme affects viral replication.

IMMUNOLOGY

Two snapshots of the TAPBPR–MHC I complex

Thomas and Tampé used two different approaches to generate complementary structures of TAPBPR in complex with MHC I (see also Cresswell).

STRUCTURAL BIOLOGY

The inner workings of an optogenetic tool

Volkov et al. found that channelrhodopsin has an intricate hydrogen-bonding network that is perturbed by light activation resulting in channel opening (see also Gerwert).

VIRAL IMMUNITY

Host RNA helps promote viral replication

Wang et al. showed that a virus-induced cytoplasmic lncRNA enhances viral replication by regulating a host cell metabolic enzyme (see also Kotzin et al.).

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