Editors' ChoiceImmunology

Papers of note in Science Immunology 2 (17)

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Sci. Signal.  28 Nov 2017:
Vol. 10, Issue 507, eaar5682
DOI: 10.1126/scisignal.aar5682

This month’s articles show how a hypha-associated fungal peptide triggers an antifungal immune response and how the lipid PIP2 sustains B cell receptor signaling.

FUNGAL INFECTION

Calibrating antifuncal responses

Verma et al. showed that the hypha-associated peptide candidalysin stimulates an IL-17–dependent immune response to Candida albicans infection (see Li et al.).

ANTIGEN RECEPTOR SIGNALING

Sustaining B cell receptor signaling

Xu et al. used live cell imaging to examine the localization of the lipid PIP2 in B cells and found that a PIP2-driven amplification loop sustains B cell receptor signaling.

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