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Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

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Sci. Signal.  05 Dec 2017:
Vol. 10, Issue 508, eaan3398
DOI: 10.1126/scisignal.aan3398

Article Information

vol. 10 no. 508

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  • Received March 30, 2017
  • Accepted November 7, 2017

Author Information

  1. Markus Muttenthaler1,2,*,
  2. Åsa Andersson1,
  3. Irina Vetter1,3,
  4. Rohit Menon4,
  5. Marta Busnelli5,6,
  6. Lotten Ragnarsson1,
  7. Christian Bergmayr7,
  8. Sarah Arrowsmith8,
  9. Jennifer R. Deuis1,
  10. Han Sheng Chiu1,
  11. Nathan J. Palpant1,
  12. Margaret O’Brien9,
  13. Terry J. Smith9,
  14. Susan Wray8,
  15. Inga D. Neumann4,
  16. Christian W. Gruber7,10,
  17. Richard J. Lewis1, and
  18. Paul F. Alewood1,*
  1. 1Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
  2. 2Faculty of Chemistry, Institute of Biological Chemistry, University of Vienna, 1090 Vienna, Austria.
  3. 3School of Pharmacy, The University of Queensland, Brisbane, Queensland 4104, Australia.
  4. 4Department of Behavioral and Molecular Neurobiology, Regensburg Center of Neuroscience, University of Regensburg, 93053 Regensburg, Germany.
  5. 5CNR–Institute of Neuroscience, 20129 Milan, Italy.
  6. 6Department of Biotechnology and Translational Medicine, University of Milan, 20129 Milan, Italy.
  7. 7Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
  8. 8Department of Cellular and Molecular Physiology, Harris-Wellbeing Preterm Birth Centre, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.
  9. 9National Centre for Biomedical Engineering Science, National University of Ireland, Galway H91 CF50, Ireland.
  10. 10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia.
  1. *Corresponding author. Email: markus.muttenthaler{at}, m.muttenthaler{at} (M.M.); p.alewood{at} (P.F.A.)


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Apr 20182421762
May 20181702230
Jun 201815947