Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 551 (7682)

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Sci. Signal.  05 Dec 2017:
Vol. 10, Issue 508, eaar6316
DOI: 10.1126/scisignal.aar6316

This week’s articles highlight proteostasis in the germ line, tumor cell survival in high-oxygen environments, and gut symbiont metabolites that affect intestinal physiology and systemic immunity.

DEVELOPMENTAL BIOLOGY

Germline proteostasis

Bohnert et al. report that factors released by nematode sperm stimulate lysosome acidification in oocytes, which in turn restores the oocytes’ ability to degrade damaged proteins.

CANCER

Tumor cell survival in high-oxygen environments

Alvarez et al. found that the cysteine desulfurase NFS1 is required for the growth of tumors in high-oxygen tissues, such as the lung, because it protects cells from oxidative damage and ferroptosis.

HOST-MICROBE INTERACTIONS

Circulating bacterial metabolites

Dodd et al. identified a metabolic pathway in the gut symbiont Clostridium sporogenes that produces aromatic amino acid metabolites that enter the circulation and influence both the permeability of the intestinal barrier and systemic immunity in mice.

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