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Paper of note in Science Translational Medicine 9 (419)

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Sci. Signal.  12 Dec 2017:
Vol. 10, Issue 509, eaar6876
DOI: 10.1126/scisignal.aar6876

This week’s article describes a way to potentially reduce neurodegeneration in patients with Huntington’s disease.

HUNTINGTON’S DISEASE

Defeating neurotoxicity with a repurposed drug

Dickey et al. report that agonists of the nuclear receptors RXR and PPARδ are neuroprotective in models of Huntington’s disease because they enhance oxidative metabolism and promote autophagy-mediated protein homeostasis.

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