Research ArticleCancer Metabolism

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

See allHide authors and affiliations

Sci. Signal.  19 Dec 2017:
Vol. 10, Issue 510, eaao6604
DOI: 10.1126/scisignal.aao6604

Article Information

vol. 10 no. 510

PubMed: 
Published By: 
Print ISSN: 
Online ISSN: 
History: 
  • Received August 12, 2017
  • Accepted November 30, 2017

Author Information

  1. Evan C. Lien1,*,
  2. Laura Ghisolfi1,
  3. Renee C. Geck1,
  4. John M. Asara2,3, and
  5. Alex Toker1,2,3,4,
  1. 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  2. 2Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215 MA, USA.
  3. 3Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  4. 4Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: atoker{at}bidmc.harvard.edu
  • * Present address: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Altmetric

Article usage

Article usage: December 2017 to January 2018

AbstractFullPdf
Dec 2017568790239
Jan 201895958107