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Papers of note in Science Translational Medicine 9 (420)

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Sci. Signal.  19 Dec 2017:
Vol. 10, Issue 510, eaar6958
DOI: 10.1126/scisignal.aar6958

This week’s articles describe ways to treat scleroderma and schizophrenia.

FIBROSIS

Reversing fibrosis through apoptosis

Lagares et al. report that ABT-263 reverses dermal fibrosis in models of the fibrotic connective tissue disorder scleroderma by blocking the antiapoptotic protein BCL-XL.

NEUROSCIENCE

Thorase ATPase, a multifunctional enzyme

Umanah et al. report that rare variants in the enzyme thorase increase the abundance of glutamate receptors in cortical neurons, resulting in behavioral abnormalities associated with schizophrenia that were reversed with the AMPA receptor antagonist Perampanel.

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