Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 358 (6369)

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Sci. Signal.  19 Dec 2017:
Vol. 10, Issue 510, eaar7667
DOI: 10.1126/scisignal.aar7667

This week’s articles explain why broad-leaved plants are susceptible to a microbial toxin that does not affect monocots; identify the enzymes that detyrosinate tubulin; and present synthetic biological systems for recording environmental signals and for translating a biochemical reaction into dynamic cellular behavior.

PLANT BIOLOGY

An extra sugar protects

Lenarčič et al. showed that plant sensitivity to a microbial cytotoxin is mediated through the sugar head groups of an abundant plant sphingolipid (see also Van den Ackerveken).

CYTOSKELETON

Tubulin carboxypeptidase identity revealed

Aillaud et al. and Nieuwenhuis et al. have identified the long-sought tubulin carboxypeptidases responsible for microtubule detyrosination (see also Akhmanova and Maiato).

SYNTHETIC BIOLOGY

A CRISPR device to record time

Sheth et al. developed a scalable strategy that can record temporal biological signals into the genomes of a bacterial population.

A rationally designed DNA-based oscillator

Srinivas et al. generated a compiler that specifies dynamic response behaviors in DNA strand displacement reactions.

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