Research ArticleCancer Immunotherapy

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

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Sci. Signal.  02 Jan 2018:
Vol. 11, Issue 511, eaan0790
DOI: 10.1126/scisignal.aan0790

Article Information

vol. 11 no. 511

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  • Received March 1, 2017
  • Accepted November 16, 2017

Author Information

  1. Yingjie Nie1,2,
  2. Jiang He3,
  3. Hidekazu Shirota1,
  4. Anna L. Trivett1,
  5. De Yang1,
  6. Dennis M. Klinman1,
  7. Joost J. Oppenheim1,*, and
  8. Xin Chen3,1,*
  1. 1Cancer Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
  2. 2Department of Research, Guizhou Provincial People’s Hospital, Guiyang, Guizhou 550002, China.
  3. 3State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, China.
  1. *Corresponding author. Email: xchen{at} (X.C.); oppenhej{at} (J.J.O.)


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