Contents
30 January 2018
Vol 11, Issue 515
Vol 11, Issue 515
Focus
- EGFR-induced cytoskeletal changes drive complex cell behaviors: The tip of the iceberg
Epidermal growth factor signaling is interconnected with cytoskeletal dynamics in cancer cells (Roth et al. and Pike et al., in 30 January 2018 issue).
Research Articles
- SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors
LAD1 coordinates EGF-stimulated changes in the cytoskeleton to support aggressive phenotypes in breast cancers.
- KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation
The cell junction–associated receptor CAR coordinates the dynamics between EGFR signaling and the cytoskeleton during cell proliferation.
- Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions
Commonly used Ca2+ indicators inhibit the Na,K-ATPase and cause cellular toxicity.
Editors' Choice
- Sensing bacterial infection
The endoplasmic reticulum–resident adaptor protein ERAdP senses bacterial c-di-AMP to stimulate an immune response.
About The Cover
Online Cover This week features a Research Article showing that the protein LAD1 mediates growth factor–stimulated changes to the cytoskeleton that supports growth and metastasis in breast cancers. The image shows staining for LAD1 (red) and filamentous actin (green) in mammary epithelial cells. [Image: Roth et al., Science Signaling]