Research ArticleCancer

SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors

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Sci. Signal.  30 Jan 2018:
Vol. 11, Issue 515, eaan0949
DOI: 10.1126/scisignal.aan0949

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LAD1 marks aggressive breast cancer

The actin cytoskeleton is a framework of filaments that gives cells shape. Dynamic regulation of the cytoskeleton coordinates complex cell behaviors, such as cell-cell communication, migration and invasion, and cell division, the regulation of which is critical to development, tissue homeostasis, and disease. Roth et al. showed that signaling by the epidermal growth factor receptor (EGFR) promoted cell migration–associated actin dynamics through the phosphorylation of the protein LAD-1 (see also the Focus by Chiasson-MacKenzie and McClatchey). LAD1 was also a marker of aggressive subtypes or cases of breast tumors in patient samples; thus, it might be a useful biomarker to inform clinical decisions.