Research ArticleCardiovascular Biology

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

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Sci. Signal.  06 Feb 2018:
Vol. 11, Issue 516, eaan3638
DOI: 10.1126/scisignal.aan3638

Article Information

vol. 11 no. 516

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History: 
  • Received April 3, 2017
  • Accepted December 31, 2017

Author Information

  1. Tomokazu Yamaguchi1,*,
  2. Takashi Suzuki1,*,
  3. Teruki Sato2,
  4. Akinori Takahashi3,
  5. Hiroyuki Watanabe2,
  6. Ayumi Kadowaki1,
  7. Miyuki Natsui1,
  8. Hideaki Inagaki4,
  9. Satoko Arakawa5,
  10. Shinji Nakaoka6,7,
  11. Yukio Koizumi1,
  12. Shinsuke Seki4,
  13. Shungo Adachi8,
  14. Akira Fukao9,
  15. Toshinobu Fujiwara9,
  16. Tohru Natsume8,
  17. Akinori Kimura10,
  18. Masaaki Komatsu11,
  19. Shigeomi Shimizu5,
  20. Hiroshi Ito2,
  21. Yutaka Suzuki12,
  22. Josef M. Penninger13,
  23. Tadashi Yamamoto3,
  24. Yumiko Imai7, and
  25. Keiji Kuba1,14,
  1. 1Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
  2. 2Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
  3. 3Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan.
  4. 4Bioscience Education and Research Support Center, Akita University, Akita 010-8543, Japan.
  5. 5Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
  6. 6Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan.
  7. 7Laboratory for Regulation of Intractable Infectious Diseases, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan.
  8. 8Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.
  9. 9Molecular Laboratory of Biochemistry, Department of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
  10. 10Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
  11. 11Department of Biochemistry, School of Medicine, Niigata University, Niigata 951-8510, Japan.
  12. 12Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan.
  13. 13Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Campus Vienna BioCenter, Vienna 1030, Austria.
  14. 14Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Tokyo 102-0076, Japan.
  1. Corresponding author. Email: kuba{at}med.akita-u.ac.jp
    • * These authors contributed equally to this work.

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