FocusCardiovascular Biology

Unraveling the CNOT: A new player in the autophagy–cell death nexus

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Sci. Signal.  06 Feb 2018:
Vol. 11, Issue 516, eaar6364
DOI: 10.1126/scisignal.aar6364

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Abstract

Autophagy plays a context-dependent role in cardiac homeostasis. In this issue of Science Signaling, Yamaguchi et al. delineate a role for CCR4-NOT–mediated mRNA deadenylation in preventing the autophagy factor Atg7 from coactivating p53-mediated transcription of cell death genes in the heart.

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