FocusCell Biology

Grking the Smoothened signal

See allHide authors and affiliations

Sci. Signal.  06 Feb 2018:
Vol. 11, Issue 516, eaar6377
DOI: 10.1126/scisignal.aar6377

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal transducer Smoothened. Two reports by Li et al. and Pusapati et al. in this issue of Science Signaling provide new insights into the role of GRK2 in HH signaling.

View Full Text