Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition

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Sci. Signal.  06 Mar 2018:
Vol. 11, Issue 520, eaal1601
DOI: 10.1126/scisignal.aal1601

Article Information

vol. 11 no. 520

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  • Received October 6, 2016
  • Resubmitted November 3, 2017
  • Accepted February 7, 2018

Author Information

  1. Douglas S. Jones1,2,
  2. Anne P. Jenney2,
  3. Brian A. Joughin1,3,
  4. Peter K. Sorger2, and
  5. Douglas A. Lauffenburger1,3,*
  1. 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  2. 2Laboratory of Systems Pharmacology, Library of Integrated Network-based Cellular Signatures Center, Harvard Medical School, Boston, MA 02115, USA.
  3. 3Koch Institute for Integrative Cancer Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  1. *Corresponding author. Email: lauffen{at}


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