Research ArticleCancer therapy

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors

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Sci. Signal.  13 Mar 2018:
Vol. 11, Issue 521, eaao3810
DOI: 10.1126/scisignal.aao3810

Article Information

vol. 11 no. 521

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History: 
  • Received July 13, 2017
  • Accepted February 2, 2018

Author Information

  1. Emilie Clement1,
  2. Hiroyuki Inuzuka1,
  3. Naoe T. Nihira1,
  4. Wenyi Wei1, and
  5. Alex Toker1,2,*
  1. 1Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  2. 2Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02215, USA.
  1. *Corresponding author. Email: atoker{at}bidmc.harvard.edu

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Jul 201898522