Research ArticleDRUG DEVELOPMENT

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

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Sci. Signal.  10 Apr 2018:
Vol. 11, Issue 525, eaao3428
DOI: 10.1126/scisignal.aao3428

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A peptide to treat inflammatory disease

Chronic inflammation promotes the development of tumors in various tissues, notably in the gastrointestinal tract. Inflammation induces proliferation and feedforward inflammatory cytokine production in cells typically through the kinases p38 and JNK, which are associated with various diseases. Maik-Rachline et al. developed a peptide that blocked the activities of p38 and JNK specifically in the nucleus. The peptide, called PERY, prevented the development of inflammation-associated colon cancer in mice. Furthermore, without detectable side effects, the peptide protected mice from chemical-induced colitis that models irritable bowel syndrome. These findings suggest that this peptide might be used to treat colitis in patients and prevent the development of colitis-induced colon cancer.