Research ArticleIon Channels

mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2

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Sci. Signal.  10 Apr 2018:
Vol. 11, Issue 525, eaao5775
DOI: 10.1126/scisignal.aao5775

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Channeling lysosomal Ca2+

Inhibition of the multiprotein complex mTORC1 alleviates pulmonary hypertension in animal models. Using mouse pulmonary arterial myocytes and transfected cells, Ogunbayo et al. identified mTORC1 inhibition as a mechanism for activation of the ion channel TPC2 that led to the mobilization of Ca2+ from lysosomes. Furthermore, they showed that TPC2 may be regulated by mTORC1 inhibition and the ligand NAADP through a common pathway. The authors suggest that modulating TPC2 activity could be a promising therapeutic strategy for pulmonary hypertension, which currently lacks effective treatments.