Research ArticleIon Channels

mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2

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Sci. Signal.  10 Apr 2018:
Vol. 11, Issue 525, eaao5775
DOI: 10.1126/scisignal.aao5775

Article Information

vol. 11 no. 525

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  • Received August 4, 2017
  • Accepted March 12, 2018

Author Information

  1. Oluseye A. Ogunbayo1,
  2. Jingxian Duan1,
  3. Jian Xiong2,
  4. Qiaochu Wang2,
  5. Xinghua Feng2,
  6. Jianjie Ma3,
  7. Michael X. Zhu2, and
  8. A. Mark Evans1,*
  1. 1Centres for Discovery Brain Sciences and Cardiovascular Sciences, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD Scotland, UK.
  2. 2Department of Integrative Biology and Pharmacology, McGovern Medical School, Program in Biochemistry and Cell Biology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  3. 3Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
  1. *Corresponding author. Email: mark.evans{at}


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