FocusMetabolism

Parkin mediates mitophagy during beige-to-white fat conversion

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Sci. Signal.  24 Apr 2018:
Vol. 11, Issue 527, eaat1082
DOI: 10.1126/scisignal.aat1082

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Abstract

In this issue of Science Signaling, Lu et al. reveal a role for Parkin-mediated mitophagy in beige-to-white adipocyte transition. In the absence of Parkin, mitochondria in thermogenic beige adipocytes are preserved even after the elimination of cold mimetic stimuli—in contrast to their typical elimination during the white transition.

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