IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs

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Sci. Signal.  15 May 2018:
Vol. 11, Issue 530, eaao4617
DOI: 10.1126/scisignal.aao4617

Article Information

vol. 11 no. 530

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  • Received July 24, 2017
  • Accepted April 27, 2018

Author Information

  1. Jie-Mei Wang1,2,*,,
  2. Yining Qiu1,*,
  3. Zhao Yang1,
  4. Hyunbae Kim1,
  5. Qingwen Qian3,
  6. Qinghua Sun4,
  7. Chunbin Zhang1,,
  8. Lei Yin5,
  9. Deyu Fang6,
  10. Sung Hong Back7,
  11. Randal J. Kaufman8,
  12. Ling Yang3,, and
  13. Kezhong Zhang1,9,
  1. 1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA.
  2. 2Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, MI 48201, USA.
  3. 3Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
  4. 4Division of Environmental Health Sciences, College of Public Health, Ohio State University, Columbus, OH 43210, USA.
  5. 5Department of Molecular and Integrative Physiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  6. 6Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  7. 7School of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea.
  8. 8Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  9. 9Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
  1. Corresponding author. Email: kzhang{at} (K.Z.);{at} (J.-M.W.); ling-yang{at} (L.Y.)
    • * These authors contributed equally to this work.

    • Present address: Bone and Joint Center, Henry Ford Health System, 6135 Woodward Avenue, Detroit, MI 48202, USA.


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