Research ArticleMUSCLE BIOLOGY

A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling

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Sci. Signal.  15 May 2018:
Vol. 11, Issue 530, eaao6847
DOI: 10.1126/scisignal.aao6847

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More muscle definition with DGKζ

The failure to maintain muscle mass is a leading risk factor for morbidity and mortality in the elderly and in cancer patients experiencing cachexia. You et al. found that the ζ isoform of diacylglycerol kinase (DGKζ) not only enhanced exercise-induced skeletal muscle growth but also limited muscle wasting in response to denervation or food deprivation. DGKζ exerted these effects independently of its DAG kinase activity. In rodents, DGKζ prevented the activation of the protein-degrading machinery that causes atrophy. Thus, increasing the abundance of DGKζ could accelerate muscle growth in response to exercise and block muscle wasting and its adverse effects.