Research ArticleMitosis

Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity

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Sci. Signal.  15 May 2018:
Vol. 11, Issue 530, eaaq1441
DOI: 10.1126/scisignal.aaq1441

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Plk1 network dynamics

Mitosis, a process of cell division, is regulated by a network of kinases, including Plk1 and Aurora A. Kettenbach et al. examined the Plk1 protein interaction network upon disruption of phosphorylation-dependent substrate targeting. From the interactions that persisted, the authors discovered that Plk1 promotes amplification of Aurora A activity during mitosis by binding to, phosphorylating, and inhibiting the phosphatase PP6. This explains the previously puzzling finding that Plk1 not only is activated by Aurora A but is also critical for Aurora A activity. The wealth of network data in this study more generally furthers our understanding of mitosis control, which may inform drug development against cancer and other diseases.