Research ArticlePhysiology

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells

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Sci. Signal.  12 Jun 2018:
Vol. 11, Issue 534, eaap7608
DOI: 10.1126/scisignal.aap7608

Article Information

vol. 11 no. 534

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History: 
  • Received August 23, 2017
  • Accepted May 4, 2018

Author Information

  1. Kenta Tsutsui1,*,
  2. Oliver J. Monfredi1,2,3,*,
  3. Syevda G. Sirenko-Tagirova1,*,
  4. Larissa A. Maltseva1,
  5. Rostislav Bychkov1,
  6. Mary S. Kim1,
  7. Bruce D. Ziman1,
  8. Kirill V. Tarasov1,
  9. Yelena S. Tarasova1,
  10. Jing Zhang1,
  11. Mingyi Wang1,
  12. Alexander V. Maltsev1,
  13. Jaclyn A. Brennan4,
  14. Igor R. Efimov4,
  15. Michael D. Stern1,
  16. Victor A. Maltsev1, and
  17. Edward G. Lakatta1,
  1. 1Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, MD 21224, USA.
  2. 2Institute of Cardiovascular Sciences, University of Manchester, Manchester M13 9NT, UK.
  3. 3Department of Cardiovascular Electrophysiology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21287, USA.
  4. 4Department of Biomedical Engineering, George Washington University, Washington, DC 20052, USA.
  1. Corresponding author. Email: lakattae{at}grc.nia.nih.gov
    • * These authors contributed equally to this work.

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