Research ArticlePain

Inhibition of somatosensory mechanotransduction by annexin A6

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Sci. Signal.  19 Jun 2018:
Vol. 11, Issue 535, eaao2060
DOI: 10.1126/scisignal.aao2060

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A blocker of osteoarthritic pain

Patients with osteoarthritis experience pain when moving or, sometimes, touching the affected joints. Raouf et al. identified proteins that bound to a toxin that inhibits mechanically induced pain, including the membrane-binding protein annexin A6. Mice lacking annexin A6 were more sensitive to mechanically induced pain, whereas overexpression of annexin A6 in sensory neurons reduced pain in a mouse model of osteoarthritis. These results suggest that strategies that increase the abundance of annexin A6 could alleviate the chronic pain of osteoarthritis.