Research ArticleInflammation

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors

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Sci. Signal.  11 Sep 2018:
Vol. 11, Issue 547, eaaj1757
DOI: 10.1126/scisignal.aaj1757

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TAZ drives inflammation

Key effectors of the Hippo pathway, YAP and TAZ, are overexpressed in various cancers. Loss of upstream kinases that inhibit the activity of these transcriptional coactivators promotes inflammation. In patient-derived xenografts and TCGA data sets, Hagenbeek et al. found that only TAZ expression correlated strongly with inflammatory cytokine transcript abundance. Expression of hyperactivated TAZ, but not YAP, in the livers of mice augmented transcription factor TEAD-mediated systemic inflammation and tissue infiltration by myeloid cells. RNA-seq analysis identified distinct gene signatures in tumor cells driven by activated YAP or TAZ, suggesting that these Hippo pathway effectors have nonredundant functions.