FocusGPCR SIGNALING

Arrestins and G proteins in cellular signaling: The coin has two sides

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Sci. Signal.  25 Sep 2018:
Vol. 11, Issue 549, eaav1646
DOI: 10.1126/scisignal.aav1646

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Abstract

Several studies have suggested that arrestin-mediated signaling by GPCRs requires G protein activation; however, in this issue of Science Signaling, Luttrell et al. documented arrestin-dependent activation of ERK1/2 by a number of GPCRs. These studies do not contradict each other, but illustrate the complexity of cellular signaling that cannot and should not be reduced to simplistic models.

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