FocusBiochemistry

The RAS-ERK pathway: A route for couples

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Sci. Signal.  30 Oct 2018:
Vol. 11, Issue 554, eaav0917
DOI: 10.1126/scisignal.aav0917

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Abstract

Data accumulated over more than three decades demonstrate that the assembly of macrocomplexes, mainly of dimers, is widespread among the members of the different tiers that constitute the RAS-ERK pathway. In this issue of Science Signaling, Yuan et al. report that MEK1 homodimerization is necessary for signal transduction through the RAF-ERK pathway and that cancer-related MEK1 mutations confer enhanced dimerization and resistance to MEK inhibitors. These findings endorse interference with RAS-ERK pathway–component dimerization as a potential therapeutic strategy in cancer patients.

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