FocusCardiovascular Biology

A cytoskeletal anchor connects ischemic mitochondrial fission to myocardial senescence

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Sci. Signal.  13 Nov 2018:
Vol. 11, Issue 556, eaav3267
DOI: 10.1126/scisignal.aav3267

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Abstract

The interplay between the actin cytoskeleton and mitochondria has been implicated in cell and tissue homeostasis and physiological function. In this issue of Science Signaling, Nishimura et al. demonstrate that inhibiting the interaction of filamin A, an actin cytoskeleton regulator, with Drp1, a modulator of mitochondrial dynamics, attenuates mitochondrial hyperfission and cardiomyocyte senescence after myocardial infarction.

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