FocusNeuroscience

Thinking through acidic Ca2+ stores

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Sci. Signal.  27 Nov 2018:
Vol. 11, Issue 558, eaau3342
DOI: 10.1126/scisignal.aau3342

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Abstract

Glutamate signaling regulates neuronal activity and synaptic plasticity, which underlies learning and memory. In this issue of Science Signaling, Foster et al. found that metabotropic glutamate receptors mediate long-term potentiation in hippocampal neurons by mobilizing acidic endolysosomal Ca2+ stores through the intracellular messenger NAADP.

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