Contents
04 December 2018
Vol 11, Issue 559
Vol 11, Issue 559
Focus
- A division of labor in mTORC1 signaling and autophagy
Autophagy and mTORC1 signaling are mediated by distinct p62 protein species (Sanchez-Garrido et al., in 4 December 2018 issue).
Research Articles
- Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing
A p62 fragment generated by caspase-8 regulates responses to nutrient availability, rather than autophagy.
- FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs
Ligand binding induces conformational changes in FZD5, activation of heterotrimeric G proteins, and Gq-dependent signaling.
Research Resource
- Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors
Bioluminescence-based biosensors enable comprehensive profiling of G protein–coupled receptor signaling bias.
Editors' Choice
- ERAD suppresses the starvation response
Endoplasmic reticulum–associated protein degradation suppresses the production of the fasting-associated hepatokine Fgf21.
About The Cover
Online Cover This week features a Research Article (see also the related Focus) that describes how a p62 fragment generated by caspase-8 regulates responses to nutrient availability, rather than autophagy. The image shows a cell expressing full-length p62 (left), which localizes with Listeria monocytogenes ΔactA, and a cell expressing the p62 fragment, called p62TRM (right), which does not participate in xenophagy and does not colocalize with the infecting bacteria. Full-length p62 and p62TRM are green and the bacterium is red. [Image: Sanchez-Garrido et al./Science Signaling]