FocusCell Biology

A division of labor in mTORC1 signaling and autophagy

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Sci. Signal.  04 Dec 2018:
Vol. 11, Issue 559, eaav3530
DOI: 10.1126/scisignal.aav3530

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Abstract

In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al. show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor.

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