Research ArticleCANCER EPIGENETICS
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition
- Arnaud Augert1,*,
- Emily Eastwood1,*,
- Ali H. Ibrahim1,
- Nan Wu1,
- Eli Grunblatt1,
- Ryan Basom2,
- Denny Liggitt3,
- Keith D. Eaton4,
- Renato Martins4,
- John T. Poirier5,
- Charles M. Rudin5,
- Francesca Milletti6,
- Wei-Yi Cheng6,
- Fiona Mack6, and
- David MacPherson1,7,†
- 1Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109, USA.
- 2Genomics and Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA 98109, USA.
- 3Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
- 4Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA 98109, USA.
- 5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- 6Pharmaceutical Research and Early Development, Roche Innovation Center, New York, NY 10016, USA.
- 7Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
- ↵†Corresponding author. Email: dmacpher{at}fredhutch.org
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Sci. Signal. 05 Feb 2019:
Vol. 12, Issue 567, eaau2922
DOI: 10.1126/scisignal.aau2922
