Signal Transduction by MAP Kinases: Regulation by Phosphorylation-Dependent Switches

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Science's STKE  28 Sep 1999:
Vol. 1999, Issue 1, pp. pe1
DOI: 10.1126/stke.1999.1.pe1

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The kinases of mitogen-activated protein (MAP) kinase cascades transmit signals through sequential phosphorylation and activation of the enzymes. However, recent evidence indicates that protein-protein interactions between the kinases themselves or with substrates or other components are also a critical means of regulation. Whitmarsh and Davis summarize these findings with emphasis on new evidence from yeast that, when phosphorylated, a MAP kinase kinase actually switches from a negative regulator that binds to and inhibits its target MAP kinase to a positive regulator of that same enzyme.

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