Editors' ChoiceCell growth

More Myc means bigger cells

Science's STKE  05 Oct 1999:
Vol. 1999, Issue 2, pp. tw1
DOI: 10.1126/stke.1999.2.tw1

The Myc family of transcription factors has been implicated in controlling cell growth and cell division, but it has not been clear how Myc accomplishes these tasks. Johnston et al. present genetic evidence that a major function of Drosophila Myc (dMyc) during fly development is to regulate cell size. Mutations in the dmyc gene caused a decrease in fly cell size and body size. Overexpression of dMyc caused an increase in cell size in the fly wing which was not dependent on the stage of development. DMyc appeared not to regulate the patterning of cells during development. The authors also found that concomittant to an increase in cell size, dMyc expression promoted the progression of cells through the G1 phase of the cell cycle into the S and G2 phases. However, the cell cycle rate was unaltered. Hence, the major effect of dMyc is to increase growth rate and final cell size rather than the rate of cell cycle progression and cell number.

Johnston, L.A., Prober, D.A., Edgar, B.A., Eisenman, R.N., and Gallant, P. (1999) Drosophila myc regulates cellular growth during development. Cell 98: 779-790. Online Journal

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