Chloride channel

Chloride channel: Tail Wagging the Channel

Science's STKE  19 Oct 1999:
Vol. 1999, Issue 4, pp. tw5
DOI: 10.1126/stke.1999.4.tw5

Improper function of the chloride channel known as the cystic fibrosis transmembrane regulator (CFTR) is associated with debilitating diseases in humans. Conductance of the channel is regulated in a complex manner. One mechanism of regulation requires phosphorylation of the channel in the so-called regulatory or R domain, which relieves an inhibitory effect of this domain on channel function. Naren et al. now provide evidence that another region, the amino-terminal tail of the channel, also has critical regulatory effects. The amino-terminal tail appears to promote phosphorylation-induced conductance of the channel through interaction with the R domain. The results present a new potential target for drug development aimed at modification of CFTR channel activity.

Naren, A.P., Cormet-Boyaka, E., Fu, J.,Villain, M., Blalock, J.E., Quick, M.W., and Kirk, K.L. (1999) CFTR chloride channel regulation by an interdomain interaction. Science 286: 544-548. [Abstract] [Full Text]