Cell death

Cell death: New Binding Partner for p75NTR in a Pro-apoptotic Pathway

Science's STKE  16 Nov 1999:
Vol. 1999, Issue 8, pp. tw1
DOI: 10.1126/stke.1999.8.tw1

The transmembrane protein p75NTR is best known as a co-receptor for the trk family of neurotrophin receptors. However, the evidence that p75NTR has a role in signaling cell death is growing. Casademunt et al. have identified a mouse cytoplasmic protein, called Neurotrophin Receptor Interacting Factor (NRIF), that binds to the cytoplasmic domain of p75NTR. The p75NTR-binding domain in NRIF was mapped to a region just upstream of its five zinc finger domains and putative nuclear localization signal. Embryonic mice expressing a truncated form of the NRIF that lacks the p75NTR-binding domain showed a 50% reduction of cell death in their retina, comparable to that observed in mice that do not express p75NTR. The authors hypothesize that NRIF could be an adaptor type molecule that directly interacts with p75NTR. NRIF might then translocate to the nucleus to regulate gene expression and apoptosis.

Casademunt, E., Carter, B.D., Benzel, I., Frade, J.M., Dechant, G., and Barde, Y.-A. (1999) The zinc finger protein NRIF interacts with the neurotrophin receptor p75NTR and participates in programmed cell death. EMBO J. 18: 6050-6061. [Abstract] [Full Text]