Plant biology

ABA Receptor Up Close

Science Signaling  08 Dec 2009:
Vol. 2, Issue 100, pp. ec391
DOI: 10.1126/scisignal.2100ec391

Plants face a variety of environmental stresses, including drought, salinity, and cold. In the face of such stresses, the plant hormone abscisic acid (ABA) triggers adaptive physiological responses. Nishimura et al. (see the Perspective by Sussman and Phillips) have now analyzed the crystal structure of one member of the ABA receptor family, PYR1 (pyrabactin resistance 1). The ABA molecule binds within an internal pocket of a dimer of PYR1, where it probably induces a conformational change. Four independent groups (Melcher et al., Miyazono et al., Santiago et al., and Yin et al.) have also analyzed ABA receptor crystal structures; in related research, a fifth group (Fujii et al.) has reported the in vitro reconstitution of the ABA signaling pathway.

N. Nishimura, K. Hitomi, A. S. Arvai, R. P. Rambo, C. Hitomi, S. R. Cutler, J. I. Schroeder, E. D. Getzoff, Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science 326, 1373–1379 (2009). [Abstract] [Full Text]

M. R. Sussman, G. N. Phillips Jr., How plant cells go to sleep for a long, long time. Science 326, 1356–1357 (2009). [Summary] [Full Text]

K. Melcher, L.-M. Ng, X. E. Zhou, F.-F. Soon, Y. Xu, K. M. Suino-Powell, S.-Y. Park, J. J. Weiner, H. Fujii, V. Chinnusamy, A. Kovach, J. Li, Y. Wang, J. Li, F. C. Peterson, D. R. Jensen, E.-L. Yong, B. F. Volkman, S. R. Cutler, J.-K. Zhu, H. E. Xu, A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature 462, 602–608 (2009). [PubMed]

K. I. Miyazono, T. Miyakawa, Y. Sawano, K. Kubota, H.-J. Kang, A. Asano, Y. Miyauchi, M. Takahashi, Y. Zhi, Y. Fujita, T. Yoshida, K.-S. Kodaira, K. Yamaguchi-Shinozaki, M. Tanokura, Structural basis of abscisic acid signalling. Nature 462, 609–614 (2009). [PubMed]

J. Santiago, F. Dupeux, A. Round, R. Antoni, S.-Y. Park, M. Jamin, S. R. Cutler, P. L. Rodriguez, J. A. Márquez, The abscisic acid receptor PYR1 in complex with abscisic acid. Nature 462, 665–668 (2009). [PubMed]

P. Yin, H. Fan, Q. Hao, X. Yuan, D. Wu, Y. Pang, C. Yan, W. Li, J. Wang, N.  Yan, Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat. Struct. Mol. Biol. 16, 1230–1236 (2009). [PubMed]

H. Fujii, V. Chinnusamy, A. Rodrigues, S. Rubio, R. Antoni, S.-Y. Park, S. R. Cutler, J. Sheen, P. L. Rodriguez, J.-K. Zhu, In vitro reconstitution of an abscisic acid signalling pathway. Nature 462, 660–664 (2009). [PubMed]