To Be γδ or Not to Be γδ? Signaling Pathways in αβ Versus γδ T Cell Maturation

Science Signaling  08 Dec 2009:
Vol. 2, Issue 100, pp. jc2
DOI: 10.1126/scisignal.2100jc2

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Maturation of T cells in the thymus involves input from a number of signaling pathways; their combined input determines whether thymic precursor cells will differentiate into mature αβ or γδ T cells. This Journal Club article highlights recent research showing that the role of Notch signaling in human T cell maturation differs from that in mice. In mice, reducing Notch gene dosage in vivo promotes γδ T cell differentiation. In humans, an increase in Notch activity early in development will trigger γδ T cell development. This research emphasizes how the molecular events controlling T cell development are fundamentally different in humans and mice.

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