CD30 is a member of the tumor necrosis factor receptor (TNFR) family associated with certain cancers of lymphoid cells. In a screen for proteins that interact with CD30, Wright and Duckett identified ARNT, the aryl hydrocarbon receptor nuclear translocator (also called hypoxia-inducible factor 1β), a transcription factor better known for its roles in mediating responses to the toxin dioxin or cellular responses to hypoxia. In a human cell line, ARNT was associated with internalized CD30. CD30 regulates gene expression in part through the transcription factor NF-κB, and depletion of ARNT-enhanced NF-κB–dependent transcription altered the association of NF-κB subunits with target promoters. Thus, signals impinging on ARNT may indirectly alter signaling by CD30 by modulating the function of the shared ARNT signaling component.
- CD30-ARNT Interaction
Signals from a cancer-associated receptor that activate a key pathway in the immune system are modulated by its binding to a stress-responsive transcription factor.Permalink: