Cell Biology

CD30-ARNT Interaction

Science Signaling  13 Jan 2009:
Vol. 2, Issue 53, pp. ec16
DOI: 10.1126/scisignal.253ec16

CD30 is a member of the tumor necrosis factor receptor (TNFR) family associated with certain cancers of lymphoid cells. In a screen for proteins that interact with CD30, Wright and Duckett identified ARNT, the aryl hydrocarbon receptor nuclear translocator (also called hypoxia-inducible factor 1β), a transcription factor better known for its roles in mediating responses to the toxin dioxin or cellular responses to hypoxia. In a human cell line, ARNT was associated with internalized CD30. CD30 regulates gene expression in part through the transcription factor NF-κB, and depletion of ARNT-enhanced NF-κB–dependent transcription altered the association of NF-κB subunits with target promoters. Thus, signals impinging on ARNT may indirectly alter signaling by CD30 by modulating the function of the shared ARNT signaling component.

C. W. Wright, C. S. Duckett, The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-κB–dependent transcription. Science 323, 251–255 (2009). [Abstract] [Full Text]