Draxin and Axon Guidance

Science Signaling  20 Jan 2009:
Vol. 2, Issue 54, pp. ec23
DOI: 10.1126/scisignal.254ec23

The developing nervous system is assembled with the help of a variety of signals and morphogens that guide the trajectory of growing neurons. Islam et al. have identified an axon guidance protein that they call draxin. Experiments in chick and mouse indicate that draxin, which appears to inhibit neurite outgrowth, is required for neurons to successfully cross the midline and form the major commissures of the brain.

S. M. Islam, Y. Shinmyo, T. Okafuji, Y. Su, I. B. Naser, G. Ahmed, S. Zhang, S. Chen, K. Ohta, H. Kiyonari, T. Abe, S. Tanaka, R. Nishinakamura, T. Terashima, T. Kitamura, H. Tanaka, Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science 323, 388–393 (2009). [Abstract] [Full Text]