PerspectiveBiochemistry

Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation

See allHide authors and affiliations

Sci. Signal.  20 Jan 2009:
Vol. 2, Issue 54, pp. pe4
DOI: 10.1126/scisignal.254pe4

You are currently viewing the abstract.

View Full Text

Abstract

Autophosphorylation of the activation loop in cis is an underappreciated and poorly understood mode of activation of protein kinases. Here, I describe four examples of protein kinases that are activated in this way, concentrating on their biochemical properties and how their autophosphorylation in cis is achieved.

View Full Text