Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation

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Sci. Signal.  20 Jan 2009:
Vol. 2, Issue 54, pp. pe4
DOI: 10.1126/scisignal.254pe4

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Autophosphorylation of the activation loop in cis is an underappreciated and poorly understood mode of activation of protein kinases. Here, I describe four examples of protein kinases that are activated in this way, concentrating on their biochemical properties and how their autophosphorylation in cis is achieved.

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