Research ArticleCancer

EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

Sci. Signal.  27 Jan 2009:
Vol. 2, Issue 55, pp. ra4
DOI: 10.1126/scisignal.2000014

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An Unexpected Route

Gliomas, the most common and most deadly form of brain tumor, are often associated with increased EGFR signaling. However, at least in part because of additional downstream mutations, most patients fail to respond to drugs that inhibit EGFR. One of the signaling pathways thought to be critical to driving glioma cell proliferation is that linking EGFR to the kinase mTOR. Fan et al. explore EGFR signaling pathways in glioma cells and confirm the importance of signaling between EGFR and mTOR to EGFR-dependent glioma cell proliferation. Unexpectedly, however, they find that the PKCα plays a key role in the signaling pathway linking EGFR to mTOR, whereas Akt—commonly thought to be a key intermediate in this pathway—does not.

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