Meeting ReportCell Biology

Emerging Roles of NAD+ and Its Metabolites in Cell Signaling

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Sci. Signal.  10 Feb 2009:
Vol. 2, Issue 57, pp. mr1
DOI: 10.1126/scisignal.257mr1

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A report on the NAD2008 symposium, Hamburg, Germany, 14 to 17 September 2008.


Nicotinamide adenine dinucleotide (NAD+) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD+ and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD+ and NAD+ phosphate metabolites adenosine 5′-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca2+ signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD+ signaling (

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