Editors' ChoicePlant biology

Closing the Loop

Sci. Signal.  17 Mar 2009:
Vol. 2, Issue 62, pp. ec99
DOI: 10.1126/scisignal.262ec99

Circadian clocks keep us, and our plants, reasonably attuned to the cycle of days and nights. Analyses of the molecules in the plant Arabidopsis that achieve this steady coordination have led to interlocking networks of logic and feedback loops of gene regulation. Pruneda-Paz et al. (see the Perspective by McClung) have now used a targeted genomics approach with yeast to add another molecule to the game: the transcription factor CHE. CHE binds to already known clock components of Arabidopsis and forms a linkage that was predicted but not yet closed, namely, bringing together a known clock component, TOC1, with its expected target gene, CCA1.

J. L. Pruneda-Paz, G. Breton, A. Para, S. A. Kay, A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock. Science 323, 1481–1485 (2009). [Abstract] [Full Text]

C. R. McClung, Linking the loops. Science 323, 1440–1441 (2009). [Summary] [Full Text]