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COVER This week's issue features a Research Article that demonstrates that an FHA domain–containing bacterial protein (Rv1827) binds to and regulates target metabolic enzymes without the enzymes undergoing prior phosphorylation, a modification previously thought to be necessary for binding of the FHA domain. Dr. Stephen Smerdon, the lead author of this study, discusses this and other findings in this week's Podcast. The image shows the structure of Rv1827 with a putative FHA accessory surface depicted in green and is based on PDB structure 2KFU. [Image: Stephen J. Smerdon, MRC National Institute for Medical Research, London, UK]

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882